Depends on what you're doing. If you're pre-loading the cache this needs to run against each client as the cache is local to a client. You can run the script centrally, and specify the ip address of each client.
Texture Cache Maintenance Utility: Preload your texture cache for optimal UI performance. Remotely manage media libraries. Purge unused artwork to free up space. Find missing media. Configurable QA check to highlight metadata issues. Aid in diagnosis of library and cache related problems.