[MANswers]

So will TC work if Kodi is not running?

No, Kodi must be running as the script has to communicate with Kodi.

I was wondering if kodi needs to be running in background for TC to work/prune obsolete data as i am using the "P" switch.

You could start kodi.exe, run the script (P/c/etc), then shutdown kodi using the script: texturecache.py power exit. Obviously this could be a little annoying if someone is in the middle of a movie, but you'll need to work that out (eg. don't shutdown kodi if it was already running etc.)

I plan to also run c after P (let me know if its a useless idea).

Running P every night might be a little excessive, but c at any time should be fine. 

Fantastic.. Thank you so much!!