[Warner306]

Add "ActivateWindow(123)" to your keymap and you can adjust many settings with your remote. These settings are saved in the madVR control panel.

And select "Load from madVR active profile" for the least hassle with madVR settings.

 Cheers Warner,

I am a little confused about what you meant by "Add "ActivateWindow(123)" to your keymap and you can adjust many settings with your remote"

I am almost ready to give up on the whole FSE issue, however if I'm not mistaken I currently need it to get the best out of my HDR material. Is that correct?

As I mentioned before, the curious thing about this issue is that FSE works everytime with MPC and maybe 1 in 10 times with DSPlayer, so I don't think there is any issue at the MadVR end, otherwise it would never work. I do feel like there must be a conflict going on here somewhere and I'm inclined to think it's at the Kodi/DSPlayer end.

If I'm loading from the MadVR active profile, do I need FSE selected in both MadVR and DSPlayer settings, or does one make the other redundant?

On a slightly different note, do you have your Kodi open at all times or do you open and force close it from your remote? I've struggled with reliable ways to close Kodi from the remote recently   

 You can change madVR processing settings from the video settings menu, which is accessible during playback. A shortcut to this menu is ActivateWindow(123).

So, you could add it to a keyboard.xml like this:

<keymap>
<FullScreenVideo>
<keyboard>
<home>ActivateWindow(123)</home>
</keyboard>
</FullScreenVideo>
</keymap>

The key "home" could be anything you want.

The only need for fullscreen exclusive mode is that it's the only way to currently get 12-bit output with HDR content with Nvidia graphics cards. This is simply due to a driver bug. So you might have to set your output to 8-bits in the GPU control panel, or allow the GPU to dither to 8-bits until this is fixed. Or launch these files with MPC. But I would just stick with 8-bits for the time being because no one's eyes are good enough to tell the difference between 8-bits with dithering and 10-bits, even with their face up to the screen. Many new UHD displays are still 8-bit, as well. This is really annoying, but it is a Nvidia driver bug, so you will have to work around it until it is fixed.

You do need to select fullscreen exclusive mode in DSPlayer. It wouldn't hurt to also select it in madVR. If you aren't doing this, it could be your problem.

I close Kodi by having my Harmony remote close Kodi with a key command when I push power. You would have to set this up in the Harmony remote software. The command is "ShutDown()" You assign this to a key command first in a keyboard.xml and then call that key command from the Harmony software. Of course, this assumes you have a Harmony remote. Occasionally, Kodi crashes. If it happens more than occasionally, you probably have a bad add-on that is not allowing Kodi to close properly.

If you put your PC to sleep, an easier way is to use Laucher4Kodi, which will close Kodi automatically on power off/sleep. It will also auto-open Kodi on resume. This is more reliable than sending a key command from a Harmony remote.