[jpjrando]

I just set up Kodi 18.0 from 17.6 and i can no more manage the items of the main menu with the native skin Estuary (for instance disable the new item Game). The screen Skin / Settings  is no more present in the system settings menu.
Thanks for your answer

[Klojum]

The screen Skin / Settings  is no more present in the system settings menu.

Go to Settings / System / Interface / Configure skin / Main menu items and enable/disable the items you want.
If you no longer have that menu screen at all, then your Kodi setup is somehow compromised.

[jpjrando]

Thanks a lot. It works fine
... but the location of this screen is not obvious

[Klojum]

... but the location of this screen is not obvious

It has been the same location from the start of Estuary.
Perhaps not everything is as obvious. "Ya cannot please everyone...".